Dr Motlana is a specialist psychiatrist, mental health advocate and entrepreneur. She helped establish a psychiatric service at Campus Health for student at Wits and consults there weekly.

She is the co-founder of a social enterprise, the Mina Foundation, chairperson of the Interactive Research and Development (SA). She is also a non executive director of the Clinix Health Group and National Health Group.

She has held executive positions including deputy CEO at Sechaba Medical Solutions, the administrator of Sizwe Medical Fund, and Clinical Head at Tara Hospital.

 She is currently a PhD student in Leadership and Change (Antioch University USA).